Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues

Figure 3

Comparability of GSE16008 dataset to other publicly available datasets. Correlations among the differential network backbone values from different human datasets in the xenobiotic metabolism network were shown. The human datasets comprise smoker versus nonsmoker data. Each data point represents a backbone node in the network. The 95%-confidence intervals of the differential network backbone values are shown for the two perturbations (axes). Blue lines show the linear regression lines computed by least squares fit. All the regression models were significant (𝑃 value < 0.05). Insets illustrate the correlation of the fold change of gene expressions.