Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues

Table 2

Statistical correlation between the in vivo versus in vitro data at various postexposure times.

	Between the backbone values		Between the fold change of genes expression
Comparison group	Pearson correlation	Spearman correlation	Pearson Correlation	Spearman Correlation
Bronchial
In vivo versus 4 h after exposure in vitro	0.73	0.77	0.25	0.13
In vivo versus 24 h after exposure in vitro	0.81	0.83	0.37	0.29
In vivo versus 48 h after exposure in vitro	0.77	0.80	0.35	0.30
Nasal
In vivo versus 4 h after exposure in vitro	0.57	0.76	0.35	0.27
In vivo versus 24 h after exposure in vitro	0.71	0.74	0.31	0.09
In vivo versus 48 h after exposure in vitro	0.65	0.73	0.26	0.14

P values < 0.05 for all comparisons.