Novel GUCA1A Mutations Suggesting Possible Mechanisms of Pathogenesis in Cone, Cone-Rod, and Macular Dystrophy Patients

Table 3

Quantitative measurements of ERG findings.

	Scotopic 0.01 ERG		Scotopic 3.0 ERG					Photopic 3.0 ERG				Photopic 3.0 flicker 30 Hz ERG
	b (ms)	b-wave (µV)	a (ms)	b (ms)	a-wave (µV)	b-wave (µV)	b/a (V)	a (ms)	b (ms)	a-wave (µV)	b-wave (µV)	P1 (ms)	N1-P1 (µV)	30 Hz Amp
Normal range	67–91	95–305	14–22	33–46	155–356	290–654	1.5–2.6	13–16	29–33	26–62	103–250	58–64	57–223
I:1
OD	86	74	23	56	116	167	1.4	22	26	10.0	11.3	42	22.7	4.43
OS	85	74	23	53	126	167	1.3	21	26	2.54	5.88	46	13.4	2.58
II:1
OD	93	211	23	49	238	423	1.8	15	41	23.6	50.9	69	51.6	25.5
OS	87	270	23	48	266	466	1.8	16	41	27.3	60.3	69	65.5	27.9
II:3
OD	84	199	23	50	218	498	2.3	17	36	41.1	112.0	64	102.0	35.3
OS	78	164	24	50	245	490	2.0	17	35	40.7	121.0	64	110.0	36.1
III:1
OD	94	81.1	20	49	234	325	1.4	18	41	14.8	14.4	70	25.3	10.1
OS	95	201	21	50	231	341	1.5	18	34	14.4	15.5	69	25.5	9.37
III:4
OD	82	251	18	47	220	510	2.3	15	28	30.1	62.4	68	72.9	35.5
OS	79	215	18	47	170	434	2.6	15	28	32.2	67.6	67	74.7	27.6