Sanguinarine Inhibits Vascular Endothelial Growth Factor Release by Generation of Reactive Oxygen Species in MCF-7 Human Mammary Adenocarcinoma Cells

Figure 4

SAN regulates VEGF release from MCF-7 cells. Effects of increasing concentrations of SAN (a), H₂O₂ (b), and NAC (c) on cell viability (MTT test) and VEGF release in MCF-7 cultures. Each histogram is the mean  ±  SD of three independent experiments performed in quadruplicate. “nd” was not detectable. Compared with normal group, ^∗𝑃<0.05, ^∗∗𝑃<0.01.

(a)

(b)

(c)