Kidney-Targeted Transplantation of Mesenchymal Stem Cells by Ultrasound-Targeted Microbubble Destruction Promotes Kidney Repair in Diabetic Nephropathy Rats

Figure 4

(a–e) Pancreatic histological sections were stained with H&E staining and observed under light microscope. Pancreatic islets structures were indicated by black arrows (b–d). (f–j) The amounts of insulin- and glucagon-producing cells (red and green, resp.) were observed by pancreatic double-label immunohistofluorescence. (k–t) Renal histological sections were stained with PAS staining and observed under light microscope. Normal rats glomeruli (k) and tubules (p). Glomerular sclerosis and glomerular mesangial expansion (l and m) and tubular dilatation (q and r) were observed in PBS group and UTMD group. MSCs-treated rats glomeruli (n) and tubules (s). Even nearly normal structure of glomeruli (o) and tubules (t) were observed in UTMD + MSCs group.

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