Effects of Repeated Central Administration of Endothelin Type A Receptor Antagonist on the Development of Neuropathic Pain in Rats

Figure 2

Comparison of mechanical threshold between BQ-123 treatment groups (15 μg, 20 μg, 25 μg, and 30 μg) and control group at 1 hour after intrathecal administration. Drug administration initiated on day 4 and continued to day 6 after sciatic nerve ligation (SNL) for 3 consecutive days. Data are presented as mean ± S.E.M and 𝑛=6/group. Significance is presented as ^∗𝑃<0.05 for BQ-123 20 μg group versus control group; ^#𝑃<0.05 and ^##𝑃<0.01 for BQ-123 25 μg group versus control group; ⁺⁺𝑃<0.01 and ⁺⁺⁺𝑃<0.001 for BQ-123 30 μg group versus control group.