Effects of Repeated Central Administration of Endothelin Type A Receptor Antagonist on the Development of Neuropathic Pain in Rats

Figure 3

Comparison of mechanical threshold between BQ-123 treatment groups (15 μg, 20 μg, 25 μg, and 30 μg) and control group 30 minutes before intrathecal administration. Assessment was made on day 7 that no drug was administered. Data presented as mean ± S.E.M and 𝑛=6/group. Significance is presented as ^∧𝑃<0.05 for BQ-123 15 μg group versus control group; ^∗∗∗𝑃<0.001 for BQ-123 20 μg group versus control group; ^###𝑃<0.001 for BQ-123 25 μg group versus control group; ⁺⁺⁺𝑃<0.001 for BQ-123 30 μg group versus control group. SNL: sciatic nerve ligation.