Topical Application of Ketoprofen Improves Gait Disturbance in Rat Models of Acute Inflammation

Figure 4

Effects of a ketoprofen patch on gait disturbance in 𝛾-carrageenan-induced arthritis in rats. Evaluation of the timing of administration (a). The ketoprofen patch was applied on the affected knee joint before (pre), before and after (pre+post), or after (post) the induction of arthritis. Walking was evaluated with a GAIT system at 4 and 24 h after the injection of 𝛾-carrageenan. A mock patch was used as a control. Each column represents the mean±SE of 13-14 animals. ^∗𝑃<0.05, ^∗∗∗𝑃<0.001, compared to STI in controls. Dose-dependent effects of the ketoprofen patch (b). A mock patch was used as a control. Each column represents the mean ± SE of 7 animals. ^∗𝑃<0.05, ^∗∗𝑃<0.01, when compared to STI in controls.

(a)

(b)