Topical Application of Ketoprofen Improves Gait Disturbance in Rat Models of Acute Inflammation

<table>Advantages of ketoprofen as a topical NSAID. Cutaneous permeation profiles of multiple NSAIDs. The concentration of the test drug measured by liquid chromatography (a) and the cumulative amount of the drug calculated from the data shown in (a), (b). <svg height="11.375" id="M32" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 42.5625 11.375" width="42.5625" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> in each condition. Hind paw hyperalgesia with direct NSAID injection in the affected site (c). Each column represents the <svg height="11.8" id="M33" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 72.949997 11.8" width="72.949997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> of 4-5 animals. Asterisks show a significant difference from control, <svg height="13.95" id="M34" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 73.300003 13.95" width="73.300003" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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BioMed Research International

fig5

Figure 5

Figure 5: Topical Application of Ketoprofen Improves Gait Disturbance in Rat Models of Acute Inflammation 