Candidate Genes for Proliferative Diabetic Retinopathy

Table 4

The reported studies of the genes involved in iron metabolism and proliferative diabetic retinopathy in subjects with type 2 diabetes.

Population	Subjects with type 2 diabetes (n)	Polymorphism (rs)	Risk genotype/allele	OR (P value)^1	Reference
Slovene population (Caucasians)	223 (PDR versus dm without PDR)	C282Y-HFE^2; H63D-HFE^2	C282Y heterozygosity; no association	3.0 (0.02); NA	[57]
USA study^3	2052 (PDR versus NDR versus dm without DR)	EPO^4 promoter-rs1617640	T allele	2.0 (<0.001)	[56]
Australian^5 population	345 (PDR versus NDR versus dm without DR)	EPO^4-rs507392; rs1617640; rs551238	CC/GG/CC; consecutively	<0.008; <0.008; <0.008; consecutively	[58]

 ¹Odds ratio and P value in logistic regression analysis; ²hemochromatosis gene; ³three European-American cohorts (Utah; GoKinD Study; and Boston). ⁴Erythropoietin gene; ⁵ninety-three percent were Caucasians of European descent, 7% were of Asian and Middle Eastern descent.