Molecular Imaging of Nonsmall Cell Lung Carcinomas Expressing Active Mutant EGFR Kinase Using PET with [124I]-Morpholino-IPQA
Figure 4
Reprehensive coronal and axial PET images obtained 24 hours after morpholino-[I]IPQA administration in mice bearing L858R EGFR (a), E746-A750 del (b), wild-type EGFR-transfected (c), and EGFR-vector ((a)–(c)) subcutaneous tumor xenografts (dot circle). Color coding in the image is set to maximize the visualization of tumor in each projection. The different scale was used in (c). L: L858R EGFR; V: vector; D: E746-A750 del; E: EGFR-vector.