Molecular Imaging of Nonsmall Cell Lung Carcinomas Expressing Active Mutant EGFR Kinase Using PET with [¹²⁴I]-Morpholino-IPQA

Table 4

Tumor-to-muscle ratio in different tumor cells in in vitro study.

	1 hr	4 hr	24 hr	48 hr
L858R/muscle	8.24±0.001	10.04±0.001^∗	13.99±0.001^∗	4.11±0.000^∗
E746-A750 del/muscle	8.94±0.001^∗	7.80±0.001	11.11±0.001^∗	5.78±0.001^∗
Wild-type EGFR/muscle	10.21±0.00^∗	8.32±0.002^∗	5.22±0.002^∗	4.00±0.001^∗
Vector/muscle	6.53±0.001	5.36±0.000	9.44±0.001	13.67±0.001^∗

Data shown as average ± standard deviation (𝑛=3 for each tumor pair). All other three cell lines were compared to L858R tumor cells at the same time point, and statistically significant difference (*𝑃<0.05) is indicated by an asterisk.