Research Article
Development of Bioadhesive Chitosan Superporous Hydrogel Composite Particles Based Intestinal Drug Delivery System
Table 1
Composition of SPHCs for preliminary screening of polymers.
| | Ingredients | P1 | P2 | P3 | P4 | P5 | P6 | P7 | P8 | P9 |
| | AA* (50% v/v) | 500 μL | 500 μL | 500 μL | 500 μL | 500 μL | 500 μL | 500 μL | 500 μL | 500 μL | | Chitosan (1% w/v) | 200 μL | — | — | 200 μL | 200 μL | 200 μL | 200 μL | 200 μL | 200 μL | | Xanthan gum (1% w/v) | — | 200 μL | — | — | — | — | — | — | — | | Sodium alginate (1% w/v) | — | — | 200 μL | — | — | — | — | — | — | | HPMC† K4M (1% w/v) | — | — | — | 200 μL | — | — | — | — | — | | HPMC† K15M (1% w/v) | — | — | — | — | 200 μL | — | — | — | — | | HPMC† K100M (1% w/v) | — | — | — | — | — | 200 μL | — | — | — | | HPMC† K4M (2% w/v) | — | — | — | — | — | — | 200 μL | — | — | | HPMC† K15M (2% w/v) | — | — | — | — | — | — | — | 200 μL | — | | HPMC† K100M (2% w/v) | — | — | — | — | — | — | — | — | 200 μL | | BIS‡ (2.5% w/v) | 100 μL | 100 μL | 100 μL | 100 μL | 100 μL | 100 μL | 100 μL | 100 μL | 100 μL | | TEMED (20% v/v) | 25 μL | 25 μL | 25 μL | 25 μL | 25 μL | 25 μL | 25 μL | 25 μL | 25 μL | | APS (20% w/v) | 25 μL | 25 μL | 25 μL | 25 μL | 25 μL | 25 μL | 25 μL | 25 μL | 25 μL | | Span 80 (10% v/v) | 30 μL | 30 μL | 30 μL | 30 μL | 30 μL | 30 μL | 30 μL | 30 μL | 30 μL | | DDW | 300 μL | 300 μL | 300 μL | 300 μL | 300 μL | 300 μL | 300 μL | 300 μL | 300 μL | | Sodium bicarbonate | 200 mg | 200 mg | 200 mg | 200 mg | 200 mg | 200 mg | 200 mg | 200 mg | 200 mg |
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AA: acrylic acid; †HPMC: hydroxypropylmethyl cellulose; ‡BIS: N,N′-methylene-bis-acrylamide; TEMED: N,N,N′,N′-tetramethylethylenediamine; APS: ammonium persulfate; DDW: double distilled water.
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