Development of Bioadhesive Chitosan Superporous Hydrogel Composite Particles Based Intestinal Drug Delivery System

Table 2

Coding and composition of factorial batches.

	F1	F2	F3	F4	F5	F6	F7	F8	F9
Coding of variables
𝑋1 level	−1	0	+1	−1	0	+1	−1	0	+1
𝑋2 level	−1	−1	−1	0	0	0	+1	+1	+1
Ingredients
AA* (50% v/v) (𝜇L)	500	500	500	500	500	500	500	500	500
Chitosan (1% w/v) (𝜇L)	100	200	300	100	200	300	100	200	300
HPMC^† K4M (2% w/v) (𝜇L)	100	100	100	200	200	200	300	300	300
BIS^‡ (2.5% w/v) (𝜇L)	100	100	100	100	100	100	100	100	100
TEMED§ (20% v/v) (𝜇L)	25	25	25	25	25	25	25	25	25
APS‖ (20% w/v) (𝜇L)	25	25	25	25	25	25	25	25	25
Span 80 (10% v/v) (𝜇L)	30	30	30	30	30	30	30	30	30
DDW¶ (𝜇L)	300	300	300	300	300	300	300	300	300
Sodium bicarbonate (mg)	200	200	200	200	200	200	200	200	200

∗AA: acrylic acid; ^†HPMC: hydroxypropylmethyl cellulose; ^‡BIS: N,N′-methylene-bis-acrylamide; §TEMED: N,N,N′,N′-tetramethylethylenediamine; ‖APS: ammonium persulfate; ¶DDW: double distilled water.