Development of Bioadhesive Chitosan Superporous Hydrogel Composite Particles Based Intestinal Drug Delivery System

Table 6

Parameters and determination coefficients of the linearization of SPHC particles based drug delivery systems.

Model		F1	F2	F3	F4	F5	F6	F7	F8	F9
Zero order	𝐾0	10.8270	10.4408	10.2299	10.6811	10.4441	10.6516	9.7257	9.9020	10.3401
	𝑟^2	0.8775	0.9175	0.9171	0.9294	0.9374	0.9404	0.9396	0.9502	0.9498
First order	𝐾1	0.0839	0.1043	0.1034	0.1128	0.1172	0.1217	0.1226	0.1274	0.1405
	𝑟^2	0.9708	0.9796	0.9795	0.9764	0.9898	0.9753	0.9681	0.9963	0.9298
Higuchi	𝐾𝐻	37.3735	35.4702	34.6312	36.1576	35.1743	35.8583	32.7297	33.0886	34.5900
	𝑟^2	0.8656	0.8767	0.8702	0.8817	0.8803	0.8823	0.8810	0.8784	0.8800
Hixson-Crowell	𝐾𝑠	0.3626	0.3246	0.3089	0.3314	0.3152	0.3251	0.2572	0.2795	0.2897
	𝑟^2	0.9475	0.9407	0.9381	0.9739	0.9653	0.9786	0.9789	0.9546	0.9861
Korsmeyer-Peppas	𝑛	0.4991	0.6165	0.5924	0.6720	0.6886	0.7246	0.7288	0.7464	0.8528
	𝑟^2	0.9883	0.9845	0.9254	0.9977	0.9844	0.9956	0.9855	0.9841	0.9857

𝐾₀, 𝐾₁, 𝐾_𝐻, 𝐾_𝑠: release rate constants; 𝑛: release exponent.