Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration

Table 1

14-3-3 isoforms in neurodegeneration.

14-3-3 isoform	Isoform-specific histology	Interacting partner and disease involvement
𝛽	Tangles in AD; LBHI in ALS; GCI in MSA	LRRK2; PD; NFL mRNA; ALS; Tau, SPRK2, FOXO1; AD; Ataxin-1; SCA1; ASK1; Epilepsy; GFAP; MS
𝛾	Tangles in AD; Lewy bodies in PD; LBH in ALS; GCI in MSA	LRRK2; PD; NFL mRNA; ALS
𝜀	Tangles in AD; Lewy bodies in PD; GCI in MSA	LRRK2; PD; Cdc25, SPRK2; AD; Ataxin-1; SCA1; GFAP; MS
𝜁	Tangles in AD; Lewy bodies in PD; Amyloid plaque in CJD; GCI in MSA	Tyrosine hydroxylase, LRRK2; PD; NFL mRNA; ALS; GSK3𝛽, tau; AD; Ataxin-1; SCA1; Huntingtin; HD; Bad, Bax; Ischemia; GFAP; MS
𝜂		Parkin, LRRK2; PD; NFL mRNA; ALS; Tau; AD
𝜎	Tangles in AD	SPRK2; AD
𝜃/𝜏	Lewy bodies in PD; GCI in MSA	Bad, Bax, LRRK2; PD; NFL mRNA; ALS