Hippocampal Gene Expression of Deiodinases 2 and 3 and Effects of 3,5-Diiodo-L-Thyronine T2 in Mouse Depression Paradigms
Figure 2
Chronic stress induces physiological and behavioural changes in a subgroup of anhedonic mice, which are not evident in mice resilient to stress. (a) A loss of sucrose preference was used to define the susceptible group, which was measured after the termination of a 10-day stress paradigm. (b) Latency to immobility in the tail suspension test was significantly shorter in stressed drug-naive animals than in control and stressed imipramine-treated groups. (c) The duration of immobility in the tail suspension test was significantly longer in stressed drug-naive than in control and stressed imipramine-treated groups. (d) In comparison to control mice, the score of coat state was significantly decreased in stressed nontreated mice and, to lesser extent, in stressed imipramine-treated animals. (e) Body weight was significantly reduced in both stressed group; it was significantly higher in imipramine-treated than in nontreated stressed groups. Data are mean ± SEM; , , and ; TST: tail suspension test.
