Sensitivity of Rabbit Ventricular Action Potential and Ca²⁺ Dynamics to Small Variations in Membrane Currents and Ion Diffusion Coefficients

Figure 2

Parameter sensitivity analysis of APD₆₀, Δ[Ca]_𝑖, Δ[Ca]_SL, and Δ[Ca]_jct sensitivities toward 10% increases in maximal transporters’ conductance and permeability. Positive value indicates direct relationship between parameter and output (e.g., enhanced L-type Ca²⁺ permeability prolongs APD₆₀), and negative value indicates indirect relationship between parameter and output. Nimrod/E-Lenth plots (left column), PLS-bar plots (right column). Nimrod/E analysis produced similar qualitative results as PLS analysis.