Sensitivity of Rabbit Ventricular Action Potential and Ca2+ Dynamics to Small Variations in Membrane Currents and Ion Diffusion Coefficients
Figure 4
Parameter sensitivity analysis of APD60, , , and sensitivities toward 5% increases in ion transporter distributions in the junctional cleft. Transporters’ distribution between sarcolemma and junctional cleft summed up to 100%. Increasing fraction of total -current in the junction by 5% is analogous to decreasing fraction of total -current in the subsarcolemma by 45% for and by 40-41% for all other currents. Positive value indicates direct relationship between distribution and output (e.g., increased density of in the junctional cleft shortens ) and negative value indicates indirect relationship between parameter and output. Nimrod/E-Lenth plots (left column), PLS-bar plots (right column). Nimrod/E analysis produced similar qualitative results as PLS analysis.
