Sensitivity of Rabbit Ventricular Action Potential and Ca2+ Dynamics to Small Variations in Membrane Currents and Ion Diffusion Coefficients
Figure 6
Parameter sensitivity analysis of , , , and sensitivities toward 10% increases in and diffusion coefficients between subcellular compartments. Positive value indicates direct relationship between diffusion coefficient and output (e.g., increased diffusion coefficient between junctional cleft and sarcolemma prolongs ) and negative sensitivity value indicates indirect relationship between parameter and output. Nimrod/E-Lenth plots (left column), PLS-bar plots (right column). Nimrod/E analysis produced similar qualitative results as PLS analysis.
