Sensitivity of Rabbit Ventricular Action Potential and Ca²⁺ Dynamics to Small Variations in Membrane Currents and Ion Diffusion Coefficients

Table 2

Fractions of total “𝑗” flux varied in the model.

Definition		Symbol	Baseline value
1	Fraction of total Na^+ current in junctional cleft	𝐹𝑥Na(jct)	0.11
2	Fraction of total background Na^+ current in junctional cleft	𝐹𝑥NaBk(jct)	0.11
3	Fraction of total Na^+-K^+ current in junctional cleft	𝐹𝑥NaK(jct)	0.11
4	Fraction of total slow delayed rectifier K^+ current in junctional cleft	𝐹𝑥Ks(jct)	0.11
5	Fraction of total Ca-activated Cl^− current in junctional cleft	𝐹𝑥Cl(Ca)(jct)	0.11
6	Fraction of total Ca-dependent L-type Ca^2+ current in junctional cleft	𝐹𝑥CaL(jct)	0.9
7	Fraction of total background Ca^2+ current in junctional cleft	𝐹𝑥CaBk(jct)	0.11
8	Fraction of total Na^+-Ca^2+ current in junctional cleft	𝐹𝑥NCX(jct)	0.11
9	Fraction of total sarcolemmal Ca^2+ pump current in junctional cleft	𝐹𝑥SLCaP(jct)	0.11

Notes: fraction of total 𝑗 flux in SL (𝐹𝑥_𝑗(SL)=1−𝐹𝑥_𝑗(jct)). In the Shannon et al. article [1]  𝐹𝑥_Cl(jct)  corresponds to  𝐹𝑥_Cl(Ca)(jct). The baseline total “𝑗” flux fraction values used in this study are the same as in [1].