Higher Plasma Pyridoxal Phosphate Is Associated with Increased Antioxidant Enzyme Activities in Critically Ill Surgical Patients

Table 2

Hematological measurements, homocysteine, vitamin B-6 status, indicators of oxidative stress, and antioxidant capacities in critically ill patients on the 1st and 7th days of admission to the surgical intensive care unit¹.

Variables	Day 1	Day 7	Δ (Day 7 − Day 1)^2
	(𝑛=37)	(𝑛=37)	(𝑛=37)
Albumin (g/L)	2.81 ± 0.14	2.76 ± 0.07	−0.05 ± 0.14
Hemoglobin (g/dL)	10.31 ± 0.36^a	9.32 ± 0.32^b	−0.99 ± 0.31
Creatinine (mg/dL)	1.90 ± 0.33	2.07 ± 0.39	0.11 ± 0.20
C-reactive protein (mg/dL)	10.54 ± 1.28	9.19 ± 1.15	−1.54 ± 1.43
Vitamin B-6 status
Plasma PLP (nmol/L)	30.64 ± 4.73	37.11 ± 4.92	6.47 ± 10.99
<20 nmol/L (𝑛, %)	16 (43.24%)	12 (32.43%)
Erythrocyte PLP (pmol/g Hb)	444.99 ± 104.88^a	669.55 ± 156.62^b	224.56 ± 92.76
Plasma PLP/Erythrocyte PLP ratio	0.11 ± 0.02	0.10 ± 0.01	−0.00 ± 3.37
Oxidative stress
Plasma homocysteine (𝜇mol/L)	18.38 ± 2.73^a	19.99 ± 2.70^b	1.61 ± 3.37
>15 𝜇mol/L (𝑛, %)	15 (40.54%)^a	22 (59.46%)^b
MDA (𝜇mol/L)	1.00 ± 0.08	1.02 ± 0.09	0.02 ± 0.06
Antioxidant capacity
Total antioxidant capacity (𝜇mol/L)	4042.28 ± 82.65^a	4243.33 ± 84.62^b	201.05 ± 66.63
SOD (U/mL)	10.60 ± 1.21	11.01 ± 1.31	0.41 ± 1.70
GST (nmol/min/mL)	4.37 ± 0.62^a	8.99 ± 0.56^b	1.75 ± 4.29
GPx (nmol/min/mL)	100.33 ± 5.52	98.92 ± 5.73	−1.41 ± 5.64

1Values are means ± standard error of mean. PLP: pyridoxal-5′-phosphate; Hb: hemoglobin; MDA: malondialdehyde; SOD: superoxide dismutase; GST: glutathione S-transferase; GPx: glutathione peroxidase.
²Δ (Day 7 − Day 1) is the value of the difference between day 7 and day 1.
^a,bValues are significantly different between day 1 and day 7; 𝑃<0.05.