Tuning Aerosol Particle Size Distribution of Metered Dose Inhalers Using Cosolvents and Surfactants

Figure 5

Concept of the design window illustrated for solution-based HFAs containing cosolvent (changing amplitude of the particle size mode, vertical tuning) and surfactants (changing location of the mode, horizontal tuning) in which particle size modulation may be achieved by manipulation of these two components that act through independent mechanisms to effect particle size change.