Tuning Aerosol Particle Size Distribution of Metered Dose Inhalers Using Cosolvents and Surfactants

Table 1

Composition of HFA 227 formulations maintaining constant fluorescein Na and ethanol concentration (𝑛=3).

Formulation	Pluronic L81 (% w/w)	Ethanol (% w/w)	Fluorescein Na (% w/w)
1.22% w/w Pluronic L81	1.22	13.3	0.04
5.45% w/w Pluronic L81	5.45	13.4	0.04
0% w/w Pluronic L81	0^∗	13.3	0.04

∗Formulation 0% w/w Pluronic L81 contained 1.22% w/w of deionized water as a replacement for Pluronic L81 to maintain mass balance.