BioMed Research International / 2013 / Article / Tab 1

Review Article

Potential Effects of Medicinal Plants and Secondary Metabolites on Acute Lung Injury

Table 1

Animal models of lung injury.

ModelCharacteristic inflammationAnimals References

Acid aspirationRupture of the alveolar-capillary barrier with intense neutrophilic infiltrate [23, 56, 105, 106]Mice
Rats
Rabbits
[42, 56, 107110]
BleomycinAcute inflammatory injury, and reversible fibrosis [23, 111]Mice
Rats
[112114]
[20, 115]
Cecal ligation and punctureVariable neutrophilic alveolar infiltrate and increased permeability [23, 43]Mice
Rats
[111, 116, 117]
[118120]
HyperoxiaEpithelial injury and neutrophilic infiltration, followed by type II cell proliferation and scarring [23, 121123]Mice
Rats
[124127]
[128]
Intrapulmonary bacteriaIncreased neutrophilic alveolar infiltrate, interstitial edema, and permeability [23, 129]Rabbits [129]
Intravenous bacteriaInterstitial edema, neutrophils sequestration, and intravascular congestion [23, 130] Mice[131]
LPSNeutrophilic inflammation with increased intrapulmonary cytokines [20, 23, 132]Mice
Rats
Sheep
[20, 45, 59, 70, 132135]
[136]
Nonpulmonary ischemia/reperfusionIncreased microvascular permeability, neutrophils recruitment, edema, and sequestration in the lungs [23, 28]Mice
Rats
[28, 137139]
Oleic acidNeutrophilic inflammation, increased permeability, and edema [22, 23, 140]Mice
Rats
[141]
[21, 22, 142]
Peritonitis by cecal ligation 
and puncture
Variable degrees
Neutrophilic alveolar infiltrate
and increased permeability [23, 143]
Rats
Rabbits
[143, 144]
[44]
Pulmonary ischemia/reperfusionIncreased pulmonary vascular permeability, neutrophil infiltration, and edema [23, 145]Mice
Rats
Rabbits
[145147]
[148]

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