Research Article
TNFα Mediated IL-6 Secretion Is Regulated by JAK/STAT Pathway but Not by MEK Phosphorylation and AKT Phosphorylation in U266 Multiple Myeloma Cells
Table 1
Median values of the measured parameters in the whole multiple myeloma patients.
| | Parameters | |
| | Male/female (number) | 22/23 (45) | | TNF alpha level (pg/mL) | 40* (3.17–308.7)† | | IL-6 level (pg/mL) | 109.7 (10.73–2695.7) | | Age (yr) | 63.3 (33–91) | | OS (month) | 22 (0.2–71.7) | | PLT (/L) | 231.1 (115–518) | | Hb (g/dL) | 11.16 (7.7–32.1) | | WBC (/L) | 6780.79 (1190–31530) | | Serum | 21.72 (0.01–414.39) | | Serum Cr | 2.35 (0.5–15.2) | | Serum Ca | 9.39 (7.2–13.3) | | LDH (IU/L) | 200 (107–392) | | 2MG (serum) | 9.48 (1.42–72.4) | | Serum albumin | 3.32 (1.8–4.8) | | Bone lesion (%) | 44% (20/45) |
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Median; †the parenthesis means the range. OS: overall survival. Hb: Hemoglobin. WBC: white blood cells, 2MG, beta-2 microglobulin.
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