Expression Systems and Species Used for Transgenic Animal Bioreactors

Table 3

Comparison of the different transgenic animal species used to produce recombinant pharmaceutical proteins.

Points to consider	Production systems
	Milk	Blood	Egg white	Seminal fluid	Urine	Silk cocoon	Others
Production level	+++++	+++++	+++++	+++	++	++	++
Investment cost	+++	+++	+++	+	+	+++	+++
Production cost	++++	++++	++++	++	+	+++++	++++
Scaling-up	++++	++++	++++	++	+	++++	+++
Collection	+++++	++++	+++++	+++	+++	+++++	+++++
Purification	+++	++	+++	++	++	+++	++
Effect on organism	+++	++	+++	+++	+++	++++	++++
Posttranslational modifications	++++	+++++	+++	+++	+++	++	++
Glycosylation	++++	++++	+++	+++	+++	++	++
Contaminant pathogens	+++	++	+++	+++	++	++++	++++
Products on the market	++++	+	++	+	+	++	+

Table adapted from [1].