The Role of MicroRNAs in Cancer Susceptibility

Table 1

List of miRSNPs evaluated in cancer susceptibility studies.

SNP category	Cancer type	SNP	Gene	OR (95% CI)	Reference
miRNA sequence
	Any cancer	rs11614913	miR-196a2	1.18 (1.03–1.34)	[24]
	Bladder cancer	rs2910164	miR-146-a	0.80 (0.71–0.90)	[12]
		rs895819	miR-27a	0.88 (0.78–0.99)	[33]
		rs2910164	miR-146-a	1.31 (1.05–1.65)	[17]
		rs11614913	miR-196a2	1.23 (1.02–1.48)	[23]
	Breast cancer	rs6505162	miR-423	0.50 (0.27–0.92)	[26]
		rs3746444	miR-499	1.25 (1.02–1.51)	[23]
		rs3746444	miR-499	1.10 (1.01–1.20)	[28]
		rs4919510	miR-608	1.62 (1.23–2.15)	[32]
	Cervical cancer	rs3746444	miR-499	1.98 (1.36–2.89)	[29]
		rs213210	miR-219-1	3.22 (1.70–6.10)	[30]
	Colorectal carcinoma	rs6505162	miR-423	2.12 (1.34–3.34)	[27]
		rs4919510	miR-608	2.72 (1.38–5.33)	[30]
	Esophageal cancer	rs213210	miR-219-1	1.75 (1.10–2.80)	[25]
		rs6505162	miR-423	0.64 (0.51–0.80)	[25]
	Gastric cancer	rs895819	miR-27a	1.48 (1.06–2.05)	[37]
	Nasopharyngeal carcinoma	rs2910164	miR-146-a	0.49 (0.35–0.69)	[13]
	Non-small cell lung cancer	rs11614913	miR-196a2	1.76 (1.34–2.32)	[19]
	Papillary thyroid carcinoma	rs2910164	miR-146-a	1.62 (1.3–2.0)	[11]
	Renal carcinoma	rs895819	miR-27a	0.71 (0.56–0.90)	[36]
Binding site
	Bladder cancer	1010A/G	HOXB5	1.48 (1.07–2.06)	[60]
		rs61764370	KRAS	1.47 (1.05–2.06)	[39]
	Breast cancer	rs7963551	RAD52	0.84 (0.75–0.95)	[50]
		rs1044129	RYR3	1.26 (1.03–1.54)	[59]
		rs334248	TGFBR1	2.2 (1.29–4.07)	[47]
	Colorectal carcinoma	rs17281995	CD86	2.93 (1.29–6.67)	[58]
		rs1051690	INSR	2.06 (1.19–3.56)	[58]
	Non-small cell lung cancer	rs61764370	KRAS	1.36 (1.07–1.73)	[38]
	Ovarian cancer	rs61764370	KRAS	1.67 (1.09–2.57)	[43]
		rs4245739	MDM4	5.5 (1.5–20.5)	[61]
	Small-cell lung cancer	rs3134615	MYCL1	2.08 (1.39–3.21)	[49]
		rs16917496	SET8	0.45 (0.22–0.94)	[54]
	Squamous cell carcinoma of the head and neck	rs1049253	CASP3	1.29 (1.07–1.56)	[56]
Biogenesis pathway
	Breast cancer	rs11786030	AGO2	2.62 (1.41–4.88)	[66]
		rs2292779	AGO2	2.94 (1.52–5.69)	[66]
	Head and neck cancer	rs1057035	DICER	0.65 (0.46–0.92)	[69]
	Non-small cell lung cancer	rs11077	XPO5	1.77 (1.07–2.91)	[68]
		rs2740348	GEMIN4	0.64 (0.42–0.99)	[67]
	Prostate cancer	rs7813	GEMIN4	2.53 (1.07–6.28)	[67]
		rs3744741	GEMIN4	0.69 (0.50–0.96)	[67]
		rs2740348	GEMIN4	0.67 (0.47–0.96)	[64]
	Renal carcinoma	rs7813	GEMIN4	0.68 (0.47–0.98)	[64]
		rs910925	GEMIN4	1.74 (1.15–1.62)	[65]
		rs3744741	GEMIN4	0.39 (0.19–0.77)	[65]