Acute Toxicity and the Effect of Andrographolide on Porphyromonas gingivalis-Induced Hyperlipidemia in Rats

Table 3

Effect of andrographolide on liver biomarkers in hyperlipidemic rats.

	Albumin (G/L)	TB (umol/L)	AP (IU/L)	ALT (IU/L)	AST (IU/L)
Group 1	14 ± 0.37*	3 ± 0.00	60.67 ± 2.82*	58 ± 0.52*	214.6 ± 8.01*
Group 2	11.67 ± 0.21	2.5 ± 0.22	84.17 ± 0.95	65.17 ± 0.87	184 ± 3.98
Group 3	13 ± 0.00*	2.5 ± 0.22	68.83 ± 0.95*	65.83 ± 2.54	216.8 ± 3.25*
Group 4	13.33 ± 0.21*	2.5 ± 0.22	63.17 ± 1.81*	59.17 ± 0.87*	238.3 ± 12.1*
Group 5	12.67 ± 0.21*	2 ± 0.00	62.67 ± 1.93*	48.33 ± 1.8*	236.5 ± 2.43*

Albumin 𝐹 (4,25) = 11.2, 𝑃 < 0.001, (TB) Total bilirubin; 𝐹 (4,25) = 4.2, 𝑃 < 0.05, (AP) Alkaline phosphatase; 𝐹 (4,25) = 27.4, 𝑃 < 0.001, (ALT) Alanine aminotransferase; 𝐹 (4,25) = 21.7, 𝑃 < 0.001, (AST) Aspartate aminotransferase; 𝐹 (4,25) = 9.9, 𝑃 < 0.001.
Group (1) vehicle; Group (2) vehicle and P. gingivalis; Group (3) simvastatin (100 mg/kg); Group (4) andrographolide 20 mg/kg; Group (5) andrographolide 10 mg/kg. Statistical Analysis of the data was carried out using a one-way analysis of variance (ANOVA) and Dennett’s post hoc test for average comparison on SPSS 18.0. Mean values ± SEM (𝑛 = 6) were used. Significance was defined as *𝑃 < 0.05 compared to G2. Values without an asterisk do not have significant difference compared to G2.