Figure 1: A 66-year-old woman for mammographic screening. (a) Digital mammogram showed a small oval-shaped, well-defined nodule (arrow) over upper-outer quadrant (UOQ) of right breast with BIRADS 0 rated by all the 3 readers. (b) Tomosynthesis revealed a nodule with lobular contour and obviously spiculated margin (arrow). The BIRADS score was rated as 4C by 1 reader and category 5 by 2 readers. The lesion was later proved pathologically to be a breast cancer (T1bN0M0).