Interleukin 1-β, Interleukin-1 Receptor Antagonist, and Interleukin 18 in Children with Acute Spontaneous Urticaria

Table 1

Demographic and clinical characteristics of children with urticaria and healthy children.

	Acute urticaria—single episode	Recurrent urticaria	Healthy children
Number	39	17	41
Age (y.)	8.56±1.67	9.61±2.45	9.36±1.57
M/F	16/23	7/10	17/24
CRP (mg/L)	11.99±7.67^∗	7.44±8.08^∗∗	1.05±0.59
WBC (10^9/L)	9.44±1.21	8.19±1.74	7.3±1.54
D-dimer	1.23±0.71^#	0.85±0.81^##	nd
𝐸 % (absolute count, cells/μL)	1.94±1.94 (236.87±158.7)	1.47±0.95 (136.14±18.13)	1.9±0.96 (177.3±60)
IgE (kU/L)	225.79±102.6	102.82±75.79	72±47.17
IgA (g/L)	1.22±0.17	1.20±0.17	1.13±0.31
IgM (g/L)	1.04±0.09	0.94±0.08	0.99±0.21
IgG (g/L)	8.53±0.59	8.54±0.66	8.63±0.98
Personal allergic disease	9	5
Family allergic disease	5	8
Symptoms suggestive of infection	21	5
UAS 1/2/3^&	12/10/17	11/3/3

Data are shown as mean ± standard error. 𝑃 values from Mann-Whitney 𝑈 test.
∗Children with single episode of acute urticaria versus control group 𝑃<0.00001.
∗∗Children with recurrent urticaria versus control group 𝑃<0.007.
^#𝑛=22, ^##𝑛=15.
&Urticaria activity score: 1 mild urticaria (0–3), 2 moderate urticaria (3-4), and 3 severe urticaria (5-6).