Accession number: accession number (gi) in the human RefSeq protein database of the National Center for Biotechnology Information, USA. Times of detection: the number of samples in which the protein was detected. Relative abundance: the ratio of the iTRAQ reporter ion to the 114 reporter ion (control). Increase ratio: the ratio of protein abundance between the second and first samples (4W/before) and between the third and first samples (8W/before). Bold: increased by more than 1.5-fold. Paired t-test P: the P value of a paired t-test between the first and second samples (4W) or between the first and third samples (8W). Bold: .