Cerebral Activation during Von Frey Filament Stimulation in Subjects with Endothelin-1-Induced Mechanical Hyperalgesia: A Functional MRI Study

Table 2

Regions of cerebral activations during painful stimulation of the ET-1 injected arm.

Lobus	Gyrus	Side	Talairach			BA	𝑡max	lowest P value
			x	y	z
Noxious mechanical stimulation
Frontal lobe		Ipsilateral	60	3	24	6	5.9	1.51𝑒−08
Frontal lobe		Contralateral	−2	−4	60	6	4.2	0.00005
Frontal lobe		Contralateral	−50	−3	41	6	8.9	7.07𝑒−13
Frontal lobe		Contralateral	−16	46	36	8	5.8	2.69𝑒−07
Frontal lobe		Contralateral	−11	56	30	9	6.8	0.000000209
Frontal lobe		Ipsilateral	50	41	8	46	5.6	0.000002
Frontal lobe		Contralateral	−41	34	16	46	6.2	0.0000000228
Frontal lobe		Contralateral	−44	22	2	47	7	2.14𝑒−09
Frontal lobe		Ipsilateral	58	9	13	44	6.4	0.0000000228
Frontal lobe		Contralateral	−51	1	19	44	11.7	2.73𝑒−023
Frontal lobe		Ipsilateral	9	52	30	9	3.9	0.00068
Frontal lobe		Ipsilateral	5	16	52	8	2.9	0.0039
Parietal lobe		Contralateral	−54	−25	38	2	9.6	5.45𝑒−020
Parietal lobe		Ipsilateral	50	−43	43	40	4.3	0.000064
Parietal lobe		Contralateral	−45	−26	20	40	13.5	1.17𝑒−32
Parietal lobe		Ipsilateral	49	−61	32	39	5.4	0.000001
Parietal lobe		Ipsilateral	55	−21	30	2	6.1	0.00000015
Temporal lobe		Contralateral	−65	−27	5	22	7.3	1.72𝑒−10
Temporal lobe		Ipsilateral	45	−61	4	37	6.8	2.09𝑒−07
Temporal lobe		Contralateral	−46	−65	3	37	7.8	1.19𝑒−11
Temporal lobe		Contralateral	−49	−62	24	39	7.9	2.14𝑒−09
Temporal lobe		Ipsilateral	67	−32	6	22	7.1	1.72𝑒−010
Occipital lobe		Ipsilateral	34	−89	9	19	2.9	0.0094
Occipital lobe		Contralateral	−35	−89	7	19	3.5	0.003
Occipital lobe		Contralateral	−27	−85	−7	18	3.9	0.00034
Occipital lobe		Ipsilateral	33	−89	1	18	3.6	0.00035
Amygdala		Contralateral	−27	−2	−10		5.1	0.000005
Limbic lobe		Ipsilateral	16	−39	−8	30	3.4	0.0093
Limbic lobe		Ipsilateral	5	−6	45	24	4.1	0.000082
Limbic lobe		Contralateral	−12	−3	47	24	3.1	0.0011
Insula		Ipsilateral	44	−35	21	13	8	5.99𝑒−7
Insula		Contralateral	−46	−26	20	13	13.3	3.4𝑒−31