Higher Incidence of Lung Adenocarcinomas Induced by DMBA in Connexin 43 Heterozygous Knockout Mice

Table 1

DMBA induced cancer incidence in Cx43^+/− and Cx43^+/+ mice divided by topography and tumor histopathological classification.

Cancer	Cx43^+/− (𝑛=75)		Cx43^+/+ (𝑛=60)
	Number of tumors	%	Number of tumors	%
Mammary gland	𝑛=36	48.00	𝑛=27	45.00
Adenoacanthoma	20	47.62	10	34.48
Adenocarcinoma type A	5	11.90	4	13.79
Adenocarcinoma type C	1	2.38	0	0.00
Carcinosarcoma	0	0.00	0	0.00
Cystic adenocarcinoma	12	28.57	12	41.38
Fibrosarcoma	1	2.38	0	0.00
undifferentiated type	1	2.38	0	0.00
Organoid	2	4.76	0	0.00
Total	42	100.00	29	100.00
Digestive tract	𝑛=20	26.67	𝑛=16	26.67
Squamous cell carcinoma	20	95.24	16	5.52
Gastric adenocarcinoma	1	47.61	0	0.00
Total	21	100.00	16	100.00
Lymphoid tissue	𝑛=32	42.67	𝑛=26	43.33
Lymphoma	32	100.00	26	100.00
Total	32	100.00	26	100.00
Skin	𝑛=10	13.33	𝑛=9	15.00
Squamous cell carcinoma	10	100.00	9	100.00
Total	10	100.00	9	100.00
Lung	𝑛=21	28.00	𝑛=7	11.66
Papillary adenocarcinoma	21	95.45	7	100.00
Bronchial carcinoma	1	4.45	0	0.00
Total	22	100.00	7	100.00
Ovary	𝑛=10	13.33	𝑛=3	5.00
Granulosa cell carcinoma	10	100.00	3	100.00
Total	10	100.00	3	100.00
Total	137		90
Number of cancer histological types per animal	1.83		1.50

Note: there are more tumors than mice in the experiment because some animals developed more than one type of cancer in the same or different organs.