Development of Microencapsulation Delivery System for Long-Term Preservation of Probiotics as Biotherapeutics Agent

Table 1

Clinical studies of appropriate probiotic strains which have convincingly demonstrated their therapeutic effect.

Most appropriate probiotic strain(s)	Therapeutic application	References
Lactobacillus plantarum 299v, Bacillus coagulans ATCC no. 31284, and Lactobacillus acidophilus L1	Hypercholesterolemia and cardiovascular disease	[33–36]
Lactobacillus rhamnosus GG	Prevention of atopy	[37, 38]
Lactobacillus rhamnosus GG, Bifidobacterium lactis, and Lactobacillus paracasei	Eczema	[39–44]
Lactobacillus rhamnosus GG, Bifidobacterium lactis, and Lactobacillus paracasei	Food allergies	[40–49]
Lactobacillus rhamnosus, Bifidobacterium lactis, Lactobacillus johnsonii,  Lactobacillus rhamnosus, and; Lactobacillus acidophilus	Lowered immunity	[50–60]
Lactobacillus rhamnosus GG, Saccharomyces cerevisiae, Lactobacillus acidophilus, and Lactobacillus plantarum 299v	Antibiotic use (during and after)	[61–72]
Lactobacillus rhamnosus GG	Nonsteroidal anti-inflammatory Drug	[73]
Lactobacillus rhamnosus GG, Saccharomyces cerevisiae	Intestinal hyperpermeability	[41, 42, 74, 75]
Lactobacillus rhamnosus GG, Lactobacillus reuteri MM53, Lactobacillus paracasei CRL431, Lactobacillus acidophilus CRL730, Lactobacillus johnsonii La1, Bifidobacterium lactis Bb12, Lactobacillus plantarum 299v, and Lactobacillus paracasei	Gastroenteritis	[40, 41, 76–85]
Lactobacillus johnsonii La1^α, Lactobacillus plantarum 299v,  and Lactobacillus rhamnosus GG	Giardia infection	[77, 86, 87]
Lactobacillus rhamnosus GG, Lactobacillus johnsonii La1, Lactobacillus plantarum 299v, Lactobacillus paracasei, and propionibacterium freudenreichii HA-101 and HA-102	Intestinal dysbiosis	[64, 65, 88–93]
Lactobacillus acidophilus,  Lactobacillus johnsonii La1	Lactose intolerance	[94–98]
Lactobacillus johnsonii La1, Lactobacillus acidophilus, and Lactobacillus rhamnosus GG	Peptic ulcer disease; Nonerosive gastritis	[50, 99–102]
Lactobacillus plantarum 299v, VSL no. 3^β	Irritable bowel syndrome	[103–105]
Lactobacillus acidophilus NCFB 1748, VSL no. 3^α	Radiation-induced diarrhoea	[106, 107]
Lactobacillus rhamnosus GG, Bifidobacterium lactis Bb12, Lactobacillus acidophilus, Saccharomyces cerevisiae, and Lactobacillus plantarum 299v	Traveller’s diarrhoea	[77, 84, 108–110]
Lactobacillus rhamnosus GG, Saccharomyces cerevisiae	Crohn’s disease	[111–114]
Escherichia coli Nissle 1917, VSL no. 3^β, Lactobacillus plantarum 299	Ulcerative colitis	[115–119]
Lactobacillus rhamnosus GG, Lactobacillus acidophilus, Lactobacillus paracasei, Lactobacillus acidophilus, and Lactobacillus delbrueckii ssp. bulgaricus strain LB-51	Prevention of colon cancer	[120–124]
Lactobacillus rhamnosus GR-1, Lactobacillus fermentum B-54, Lactobacillus fermentum RC-14, and Lactobacillus acidophilus	Urinary tract infection	[125–132]
Lactobacillus acidophilus, Lactobacillus rhamnosus GG, Lactobacillus rhamnosus GR-1, and Lactobacillus fermentum RC-14	Vaginal candidiasis (thrush)	[133–138]