Development of Microencapsulation Delivery System for Long-Term Preservation of Probiotics as Biotherapeutics Agent

Table 4

Advantage and disadvantages of extrusion technique.

Advantages	Disadvantages
(i) Simple and cheap method that uses a gentle operation; (ii) No damage to the probiotic cell; (iii) Gives high probiotic viability [29]; (iv) Does not involve deleterious solvent; (v) Done under aerobic and anaerobic conditions	(i) Difficult to use for large scale production due to slow formation of microbeads; (ii) Very poor payload of typically 8%; (iii) Susceptibility of carbohydrate towards damage and structural defect, a larger size distribution; (iv) Limited choice of wall material [146, 147].