Research Article

Comparison of Prostate-Specific Promoters and the Use of PSP-Driven Virotherapy for Prostate Cancer

Figure 5

Comparison of in vivo activity of prostate-specific and RSV promoters. PPC-1 xenograft tumors were established and transduced by Ad-lacZ as described in Section 2. The tumors were harvested in 72 hr and processed to whole-mount tumor X-gal staining. Shown is X-gal staining of tumors transduced by  pfu AdPBlacZ (a),  pfu AdPSAlacZ (b),  pfu AdRSVlacZ (c), and  pfu AdRSVlacZ (d). Untreated control PPC-1 tumor did not show blue cells after X-gal staining (not shown).