The Ehrlich Tumor Induces Pain-Like Behavior in Mice: A Novel Model of Cancer Pain for Pathophysiological Studies and Pharmacological Screening
Figure 1
The Ehrlich tumor induces pain and paw edema/tumor growth in a dose-dependent manner. The Ehrlich tumor cells (1 × 104–7) or saline (25 μL) was injected subcutaneously in the paw. (a) The intensity of mechanical hyperalgesia, (b) thermal hyperalgesia, (c) paw edema/tumor growth, and (d) overt pain-like behavior was evaluated between 0 and 12 days at every-other-day intervals after injection of tumor cells or saline; , representative of two experiments. * compared with saline; ** compared with saline and the dose of 104; # compared with saline and the doses of 104 and 105; ## compared with saline and the doses of 1 × 104–6.
