The Ehrlich Tumor Induces Pain-Like Behavior in Mice: A Novel Model of Cancer Pain for Pathophysiological Studies and Pharmacological Screening
Figure 3
Thermal inactivation of the Ehrlich tumor cells abolishes pain and paw edema/tumor growth. The Ehrlich tumor cells (1 × 106) were inactivated by cold followed by heat. Mice received 25 μL of inactivated tumor cells, viable tumor cells (1 × 106), or saline. (a) The intensity of mechanical hyperalgesia, (b) thermal hyperalgesia, and (c) paw edema/tumor growth was evaluated on days 2–12 after injection of the inactivated Ehrlich tumor cells, viable tumor cells, or saline. Mice received 1 × 107 of inactivated tumor cells, viable cells, or saline and (d) the overt pain was evaluated on the 8th day after injection; , representative of two experiments. * compared with the saline, and # compared with the viable 1 × 106 or 1 × 107 tumor cells.
