BioMed Research International / 2013 / Article / Fig 2

Research Article

5-Lipoxygenase Deficiency Reduces Acetaminophen-Induced Hepatotoxicity and Lethality

Figure 2

5-LO participates in acetaminophen (APAP)-induced lethality. WT mice and 5-LO−/− mice were treated with APAP (3 g/kg) or saline per oral. The lethality induced by APAP was monitored at 6 h intervals during 72 h. , representative of three separate experiments. * compared to WT mice treated with APAP, Kaplan-Meier method, followed by the log-rank test.

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