Figure 2: 5-LO participates in acetaminophen (APAP)-induced lethality. WT mice and 5-LO−/− mice were treated with APAP (3 g/kg) or saline per oral. The lethality induced by APAP was monitored at 6 h intervals during 72 h. , representative of three separate experiments. * compared to WT mice treated with APAP, Kaplan-Meier method, followed by the log-rank test.