Association of CILP2 and ACE Gene Polymorphisms with Cardiovascular Risk Factors in Slovak Midlife Women

Table 4

Anthropometrical, biochemical variables and blood pressure according to ACE genotypes in Slovak women.

Parameter	𝐴𝐶𝐸 genotypes			DD versus ID versus II		II versus ID/DD			Menopausal status * 𝐴𝐶𝐸
	DD	ID	II	𝐹	𝑃^a	𝐹	𝑃^a	𝑃^b	𝑃
	𝑛=111	𝑛=130	𝑛=73
Weight (kg)	73.30±15.91	72.86±15.27	73.61±15.10	0.062	0.940	0.024	0.877
WC (cm)	84.36±13.84	85.78±14.95	87.38±14.35	0.697	0.499	1.018	0.314
HC (cm)	105±11.54	104±10.30	105±11.20	0.549	0.578	0.347	0.556
BMI (kg/m^2)	27.24±5.85	27.41±5.56	27.56±5.34	0.021	0.979	0.027	0.868
WHR	0.80±0.07	0.82±0.09	0.83±0.08	2.422	0.090	1.162	0.282
GMT (µkat/L)	0.41±0.38	0.39±0.35	0.42±0.51	0.135	0.873	0.121	0.729
ALT (µkat/L)	0.34±0.22	0.33±0.20	0.30±0.17	1.109	0.331	1.990	0.159
UA (µmol/L)	257±69.37	254±64.61	258±66.42	0.096	0.908	0.031	0.860
TC (mmol/L)	5.49±1.03	5.50±1.07	5.23±0.97	2.189	0.114	4.393	0.037	0.035	0.377
TG (mmol/L)	1.49±1.04	1.34±0.68	1.43±0.89	1.091	0.337	0.008	0.927
	𝑛=110	𝑛=130	𝑛=73
Bilirubin (µmol/L)	8.62±4.06	9.38±4.80	8.53±3.33	1.354	0.260	0.712	0.399
	𝑛=111	𝑛=130	𝑛=72
Glucose (mmol/L)	5.02±1.38	4.98±1.56	5.01±1.00	0.070	0.933	0.008	0.928
	𝑛=103	𝑛=118	𝑛=68
HDL-C (mmol/L)	1.57±0.41	1.60±0.46	1.54±0.38	0.393	0.676	0.480	0.489
LDL-C (mmol/L)	3.27±0.99	3.33±0.95	3.03±0.83	2.619	0.075	5.011	0.026	0.027	0.975
apoA1 (g/L)	1.73±0.26	1.75±0.59	1.62±0.24	1.855	0.158	3.646	0.057
apoB (g/L)	0.95±0.25	0.95±0.28	0.89±0.20	1.603	0.203	3.172	0.076
apoB-to-apoA1	0.57±0.19	0.57±0.18	0.56±0.17	0.019	0.981	0.035	0.851
TC-to-HDL-C	3.74±1.14	3.69±1.12	3.58±1.10	0.548	0.579	0.981	0.323
non-HDL-C	3.94±1.09	3.93±1.06	3.66±0.96	2.268	0.105	4.549	0.034	0.023	0.951
LDL-C-to-HDL-C	2.26±0.95	2.25±0.88	2.12±0.90	0.660	0.517	1.319	0.252
log(TG-to-HDL-C)	−0.08±0.29	−0.12±0.30	−0.10±0.29	0.492	0.612	0.004	0.949
	𝑛=98	𝑛=118	𝑛=70
sBP (mmHg)	123±17.77	123±18.71	121.03±13.65	0.781	0.459	1.509	0.220
dBP (mmHg)	79±9.41	79±11.20	78.04±14.56	0.260	0.771	0.451	0.503

WC: waist circumference; HC: hip circumference; BMI: body mass index; WHR: waist-to-hip ratio; GMT: gamma glutamyl transpeptidase, ALT: alanine aminotransferase; UA: uric acid; TC: total cholesterol; TG: triglycerides, HDL-C: high density lipoprotein cholesterol; LDL-C: low density lipoprotein; apoA1: apolipoprotein A1; apoB: apolipoprotein B; sBP: systolic blood pressure; dBP: diastolic blood pressure. Values represent mean ± SD. ^aAdjusted for age; ^badjusted for age, BMI, and WHR.