Association of CILP2 and ACE Gene Polymorphisms with Cardiovascular Risk Factors in Slovak Midlife Women

Table 6

Regression analysis of selected confounder effects on lipid, and lipoprotein levels, and atherogenic indices in Slovak women.

Dependent variable	Independent variable	𝐵	SE	Beta	𝑃	95.0% CI for 𝐵		Collinearity statistics tolerance
TC	ln age	1.72	0.52	0.19	0.001	0.70	2.73	0.99
𝑛=292	Current smoker	0.32	0.09	0.20	0.001	0.14	0.50	0.98
	ACE: II versus ID/DD	0.40	0.14	0.16	0.005	0.12	0.69	0.98
	𝑅^2 = 0.085, adjusted 𝑅^2 = 0.075, SE = 1.008
	Excluded variables: menopausal status, BMI, WHR, former sport activities, and recent sport activities, current smoker.
LDL-C	ln age	1.25	0.51	0.15	0.016	0.24	2.26	0.99
𝑛=259	Current smoker	0.29	0.09	0.19	0.002	0.11	0.47	0.98
	ACE: II versus ID/DD	0.37	0.14	0.16	0.009	0.10	0.65	0.98
	CILP2: GT/TT versus GG	0.42	0.20	0.13	0.035	0.03	0.81	1.00
	𝑅^2 = 0.086, adjusted 𝑅^2 = 0.071, SE = 0.924
	Excluded variables: menopausal status, BMI, WHR, former sport activities, and recent sport activities.
non-HDL-C	ln age	1.52	0.59	0.16	0.010	0.37	2.67	0.91
𝑛=259	WHR	2.39	0.84	0.17	0.005	0.73	4.05	0.91
	Current smoker	0.33	0.10	0.20	0.001	0.14	0.53	0.98
	ACE: II versus ID/DD	0.41	0.16	0.16	0.008	0.11	0.72	0.97
	CILP2: GT/TT versus GG	0.52	0.22	0.14	0.018	0.09	0.94	1.00
	𝑅^2 = 0.136, adjusted 𝑅^2 = 0.119, SE = 1.009
	Excluded variables: menopausal status, BMI, former sport activities, and recent sport activities.
HDL-C	ln age	0.49	0.20	0.14	0.017	0.09	0.89	0.92
𝑛=282	ln BMI	−0.59	0.14	−0.28	<0.001	−0.86	−0.32	0.69
	WHR	−0.89	0.35	−0.17	0.010	−1.57	−0.21	0.67
	CILP2: GT/TT versus GG	−0.21	0.08	−0.14	0.009	−0.36	−0.05	0.99
	𝑅^2 = 0.180, adjusted 𝑅^2 = 0.168, SE = 0.370
	Excluded variables: menopausal status, former sport activities, recent sport activities, and current smoker.
apoB	ln BMI	0.26	0.08	0.19	0.001	0.10	0.41	0.99
𝑛=282	Current smoker	0.05	0.02	0.12	0.038	0.00	0.09	1.00
	CILP2: GT/TT versus GG	0.14	0.05	0.15	0.011	0.03	0.24	1.00
	𝑅^2 = 0.075, adjusted 𝑅^2 = 0.065, SE = 0.249
	Excluded variables: age, menopausal status, WHR, former sport activities, and recent sport activities.
apoB-to-apoA1	ln BMI	0.23	0.05	0.25	<0.001	0.13	0.34	0.99
𝑛=282	Current smoker	0.04	0.02	0.13	0.026	0.00	0.07	1.00
	CILP2: GT/TT versus GG	0.11	0.04	0.16	0.004	0.03	0.18	1.00
	𝑅^2 = 0.106, adjusted 𝑅^2 = 0.096, SE = 0.172
	Excluded variables: age, menopausal status, WHR, former sport activities, and recent sport activities.
ln TC-to-HDL-C	ln BMI	0.37	0.10	0.24	<0.001	0.17	0.57	0.70
𝑛=282	WHR	0.71	0.25	0.18	0.005	0.21	1.20	0.70
	Current smoker	0.06	0.03	0.13	0.022	0.01	0.11	1.00
	CILP2: GT/TT versus GG	0.17	0.06	0.16	0.004	0.06	0.29	1.00
	𝑅^2 = 0.182, adjusted 𝑅^2 = 0.170, SE = 0.273
	Excluded variables: age, menopausal status, former sport activities, and recent sport activities.
ln LDL-C-to-HDL-C	ln BMI	0.61	0.12	0.28	<0.001	0.37	0.85	0.99
𝑛=282	Current smoker	0.08	0.04	0.13	0.024	0.01	0.15	1.00
	CILP2: GT/TT versus GG	0.25	0.08	0.17	0.003	0.08	0.42	1.00
	𝑅^2 = 0.124, adjusted 𝑅^2 = 0.115, SE = 0.395
	Excluded variables: age, menopausal status, WHR, former sport activities, and recent sport activities.