Combination of Telmisartan with Cisplatin Controls Oral Cancer Cachexia in Rats

Table 1

Effect of cisplatin and combination of cisplatin with telmisartan on food intake and serum lipid profile.

Parameters	CON	COC	COCT	ORN	ORC	ORCT
Food intake (gm/group/day)	143.73 ±9.24	141.11 ±9.21	144.53 ±10.57	125.37 ±13.15	132.78 ±7.63	140.56 ±8.70
Serum cholesterol (mg/dL)	82.13 ±5.56	78.51 ±4.97	78.31 ±2.91	45.84 ±1.60^∗	67.43 ±4.75	74.88 ±8.14^#
Serum VLDL (mg/dL)	26.88 ±1.51	28.66 ±0.64	31.78 ±2.28	17.15 ±0.78^∗	107.73 ±2.33	27.52 ±1.42^#
Serum triglyceride (mg/dL)	134.41 ±7.56	143.34 ±3.22	158.93 ±11.42	85.77 ±3.93^∗	107.73 ±14.12	130.54 ±6.20^#
Serum HDL (mg/dL)	81.93 ±5.86	72.87 ±3.64	90.34 ±6.21	40.33 ±8.50^∗	56.20 ±6.52	78.78 ±4.11^∗

∗Significantly different from control group (𝑃<0.05).
#Significantly different from cancer control group (𝑃<0.05).
CON: normal control.
COC: control treated with cisplatin (0.23 mg/kg).
COCT: control treated with cisplatin (0.23 mg/kg) + telmisartan (5 mg/kg/day).
ORN: oral cancer control.
ORC: oral cancer treated with cisplatin (0.23 mg/kg).
ORCT: oral cancer treated with cisplatin (0.23 mg/kg) + telmisartan (5 mg/kg/day).