Combination of Telmisartan with Cisplatin Controls Oral Cancer Cachexia in Rats

Table 2

Effect of cisplatin and combination of cisplatin with telmisartan on hemodynamic parameters.

Parameters	CON	COC	COCT	ORN	ORC	ORCT
Systolic blood pressure (mmHg)	154.15 ±10.19	176.84 ±6.13	140.69 ±0.032	177.74 ±6.52	164.03 ±2.77	139.48 ±5.94^#
Diastolic blood pressure (mmHg)	136.95 ±7.66	145.16 ±1.81	123.95 ±1.14	147.37 ±2.81^∗	135.40 ±1.33	124.41 ±1.46^#
Heart rate (beats per minute)	251.95 ±7.35	247.68 ±1.93	238.50 ±3.01	254.89 ±5.25	227.54 ±5.60	223.71 ±3.08

∗Significantly different from control group (𝑃<0.05).
#Significantly different from cancer control group (𝑃<0.05).
CON: normal control.
COC: control treated with cisplatin (0.23 mg/kg).
COCT: control treated with cisplatin (0.23 mg/kg) + telmisartan (5 mg/kg/day).
ORN: oral cancer control.
ORC: oral cancer treated with cisplatin (0.23 mg/kg).
ORCT: oral cancer treated with cisplatin (0.23 mg/kg) + telmisartan (5 mg/kg/day).