Increased Expression of Epidermal Growth Factor Receptor (EGF-R) in Patients with Different Forms of Lung Fibrosis

Figure 1

Representative tissue microarray section immunostained with monoclonal antibody EGFR demonstrating diffuse cytoplasmic reaction (dark brown) of strong intensity within hyperplastic alveolar epithelium (arrows) immediately adjacent to fibroblastic foci in patients with IPF (𝑛=20), evidence that was further verified by double immunohistochemistry analysis revealing strong colocalization (light brown with red) of EGFR and SP-A (arrows).

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