Figure 1: (a) Schematics of a guide box C/D snoRNA structure and the interaction between a snoRNA and target RNAs. (b) Base-pairing interactions between an artificial box C/D RNA and target RNAs. The arrows indicate potential targets of 2′-O-methylation. Uppercase letters in the target pre-mRNA sequences correspond to exons, and small letters indicate the intron sequences. Boxes C and D are indicated as GUGAUGA and CUGA enclosed in rectangles, respectively. The nucleotides to be complementary to target nucleotides are shown as C. RNA7D* and RNA8D* were constructed by changing the CUGA sequence in both box D and D′ to AAAA.