| | Year(s) | Activity reported | References |
| | 1915 | Dengue epidemic reported in PR | [20] | | 1924 | 1st recorded epidemic of dengue in the Caribbean-Gulf-Atlantic region begun in the VI | [20] | | 1941–1946 | Dengue epidemic reported in PR | [20] | | 1963 | Epidemic of ≈27,000 cases (DENV-3) in PR | [55, 56] | | 1968-1969 | DENV-2 (only) epidemic, 1st report of DENV-2 in PR, 16,665 cases | [57] | | 1970–1974 | Sporadic DENV-2 cases reported in PR | [20, 57] | | 1975 | DHF suspected among 3 serologically confirmed dengue cases, shock seen in 1 patient in PR - DHF described for the 1st time in the Western Hemisphere | [20, 57] | | 1977-1978 | DENV-1 outbreak in PR, ≈12,700 cases, 1st report of DENV-1 in PR, after DENV-2 and DENV-3 reports from earlier during that year | [58, 59] | | 1978 | DENV-1 outbreaks in VI | [20] | | 1981–1983 | DENV-1 and DENV-4 outbreaks in PR, 1st reports of DENV-4 in both PR and the Americas | [60, 61] | | 1985 | 2 DHF cases associated with DENV-4 in PR | [20, 62] | | 1986 | Dengue epidemic in PR associated with DENV-4, 10,659 cases, 31 DHF cases, 3 deaths | [62] | | 1987 | 17 DHF cases in PR, 1 death | [20] | | 1988 | 8 DHF cases in PR | [20] | | 1989 | DENV-1, -2, and -4 cases reported in PR, including 12 DHF cases, 5 deaths | [20] | | Dengue cases reported in the VI | [20] | | 1990 | 6 DHF cases in PR, 1 death | [20] | | Dengue cases reported, DENV-1, -2, and -4 involved in outbreaks, 1st report of DENV-4 in the VI | [20] | | 1991 | 14 DHF cases in PR, 1 death | [20] | | 1994 | ≈24,700 cases of dengue reported in PR | [63] | | 1998 | >17,000 dengue cases reported in PR, 173 DHF cases, 9 deaths, all 4 serotypes isolated | [64] | | 1999 | All 4 serotypes reported present in PR, 34 DHF cases (6 deaths), 4,993 dengue cases | [20] | | 2000 | DENV-1, -2 and -3, isolated in PR, 24 DHF cases, 2,433 dengue cases | [20] | | 2005 | Dengue reported in blood donors from PR, DENV-2 and DENV-3 isolated | [4] | | Dengue epidemic reported in St. Croix, VI | [65] | | 2007 | Epidemic caused by DENV-3, -2, -1, and -4 (in order of frequency) in PR, more than 10,000 cases, 227 DHF cases, 40 deaths. Dengue reported in blood donors from PR | [66] | | 2010 | Largest epidemic in PR history, DENV-1, -4, -2, and -3 isolated (in order of frequency), 26,766 cases reported, 448 DHF cases, 128 deaths. Dengue reported in blood donors from PR, DENV-1, DENV-4, and DENV-2 isolated | [67] | | 2012 | Dengue epidemic in PR, 12,877 cases reported, DENV-1 and -4 isolated | [68] | | Dengue epidemic in the VI | [69] | | 2013* | Dengue epidemic in PR, >5,000 cases reported, DENV-1 and -4 isolated | [70] |
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