Use of Magnetic Folate-Dextran-Retinoic Acid Micelles for Dual Targeting of Doxorubicin in Breast Cancer

Table 2

Composition of different formulations investigated in preparation of doxorubicin loaded in magnetic micelles of FA/DEX-RA using irregular factorial design.

Run	Copolymer content; (mg/100 mL)	MNPs; (% of copolymer weight)	Shaking time (h)	Shaking rate (rpm)	Temperature (°C)
𝑃20𝐹25𝑡1𝑅75𝑇60	20	25	1	75	60
𝑃20𝐹33𝑡1𝑅75𝑇40	20	33	1	75	40
𝑃30𝐹25𝑡0.5𝑅75𝑇40	30	25	0.5	75	40
𝑃30𝐹33𝑡0.5𝑅150𝑇40	30	33	0.5	150	40
𝑃20𝐹33𝑡0.5𝑅75𝑇60	20	33	0.5	75	60
𝑃20𝐹25𝑡0.5𝑅150𝑇40	20	25	0.5	150	40
𝑃30𝐹25𝑡0.5𝑅75𝑇60	30	25	0.5	75	60
𝑃30𝐹25𝑡0.5𝑅150𝑇60	30	25	0.5	150	60
𝑃20𝐹33𝑡1𝑅150𝑇40	20	33	1	150	40
𝑃20𝐹33𝑡1𝑅150𝑇60	20	33	1	150	60
𝑃30𝐹33𝑡1𝑅75𝑇60	30	33	1	75	60
𝑃30𝐹25𝑡1𝑅150𝑇40	30	25	1	150	40