Use of Magnetic Folate-Dextran-Retinoic Acid Micelles for Dual Targeting of Doxorubicin in Breast Cancer

Table 3

Particle size, loading efficiency, release efficiency (RE₃%), and Fe₂O₃ loading efficacy % of different doxorubicin loaded in folate-targeted DEX/RA magnetic micelles (mean ± SD; 𝑛=3).

Formulation code	Particle size	PDI	Loading efficiency %	RE3 %	Fe3O4 loading efficacy %
𝑃20𝐹25𝑡1𝑅75𝑇60	119.0±4.5	0.4±0.0	100.0±0.0	100.2±1.0	7.0
𝑃20𝐹33𝑡1𝑅75𝑇40	122.0±5.2	0.3±0.0	83.0±0.0	86.9±1.3	9.0
𝑃30𝐹25𝑡0.5𝑅75𝑇40	145.0±8.6	0.4±0.0	92.0±0.5	81.1±1.3	11.0
𝑃30𝐹33𝑡0.5𝑅150𝑇40	117.0±1.7	0.3±0.0	90.0±0.2	61.2±0.9	7.0
𝑃20𝐹33𝑡0.5𝑅75𝑇60	115.0±9.4	0.4±0.1	86.0±0.5	57.4±2.4	3.0
𝑃20𝐹25𝑡0.5𝑅150𝑇40	154.0±9.4	0.3±0.1	91.0±0.4	79.8±0.7	5.0
𝑃30𝐹25𝑡0.5𝑅75𝑇60	146.0±16.3	0.4±0.0	73.0±0.4	71.4±1.0	3.5
𝑃30𝐹25𝑡0.5𝑅150𝑇60	137.0±1.2	0.3±0.0	97.0±0.5	62.9±2.8	6.4
𝑃20𝐹33𝑡1𝑅150𝑇40	135.0±26.4	0.4±0.1	100.0±0.0	81.3±2.0	7.0
𝑃20𝐹33𝑡1𝑅150𝑇60	109.0±4.3	0.5±0.0	100.0±0.0	71.7±3.8	4.1
𝑃30𝐹33𝑡1𝑅75𝑇60	164±7.6	0.4±0.1	86.0±0.4	57.8±2.9	2.5
𝑃30𝐹25𝑡1𝑅150𝑇40	112.0±2.6	0.3±0.0	94.0±0.0	66.4±2.7	13. 5