The Influence of Hemocoagulation Disorders on the Development of Posttraumatic Cerebral Infarction and Outcome in Patients with Moderate or Severe Head Trauma

Table 5

Association between demographic and hemocoagulative characteristics, GCS, PTCI, and poor outcome (GOS≤3) among 265 patients with moderate or severe head trauma.

Clinical factors	Univariate analysis			Multivariate analysis
	OR	95% CI	P value	OR	95% CI	P value
Gender (male)	1.418	0.838–2.397	0.193	NI	—	—
Age (20–40 ys)	0.833	0.565–1.288	0.525	NI	—	—
Admission GCS scores (3–5)	3.837	1.276–7.644	0.001^b	5.953	1.351–13.013	0.009^b
Thrombocytopenia	1.632	1.108–3.960	0.025^a	2.276	0.473–3.438	0.630
PT abnormal	1.272	0.757–2.140	0.364	NI	—	—
APTT abnormal	1.426	1.218–3.833	0.013^a	1.418	1.205–3.853	0.016^a
Fibrinogen abnormal	2.372	1.193–4.718	0.003^b	3.327	1.160–7.668	0.002^b
D-dimer (>2 mg/L)	2.472	1.263–4.845	0.012^a	2.489	1.242–4.989	0.047^a
DIC scores (≥5)	3.403	1.221–7.734	0.003^b	4.102	2.047–10.223	0.000^b
Presence of PTCI	3.281	1.238–8.699	0.017^a	2.542	0.931–6.941	0.069

OR: odds ratio; CI: confidence interval; NI: not included in the multivariate regression analysis; GCS: Glasgow Coma Score; PT: prothrombin time; APTT: activated partial thromboplastin time; DIC: disseminated intravascular coagulation; PTCI: posttraumatic cerebral infarction.
^a𝑃<0.05 marked statistical significance.
^b𝑃<0.01 more marked statistical significance.